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Therefore, dopamine itself should be involved in the avoidance of ferroptosis through multiple means including anti-oxidative properties and suppression of GPX4 degradation, the latter of which also leads to an anti-oxidative effect in DA neurons

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Based on this mechanism, normalizing excess glutamate levels by metabotropic glutamate group 2/3 receptor agonists has led to potential identification of the first non-monoaminergic target with comparable efficacy as conventional antipsychotic drugs for treating positive and negative symptoms of schizophrenia

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For instance, FT3 levels may remain in the low-normal reference range in a significant subset of thyroidectomized patients receiving replacement doses of LT4 (39)

Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux